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Key Features:
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Ultra-Compact Design: One of the smallest triple quadrupole LC/MS systems available, reducing laboratory footprint while maintaining high performance.
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High Sensitivity & Specificity: Optimized ion optics and collision cell design deliver superior limits of detection for trace-level quantitation.
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Robust Quantitative Performance: Reliable, reproducible quantitation across complex sample matrices.
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Fast Polarity Switching: <20 ms switching enables simultaneous detection of positive and negative ions within a single run.
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Advanced Collision Cell: Linear collision cell (LCID) for efficient fragmentation and high signal-to-noise ratios.
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High Data Acquisition Speed: Supports UHPLC peak widths with fast MRM (multiple reaction monitoring) transitions.
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Ease of Use: Streamlined setup and reduced maintenance with accessible components and built-in diagnostics.
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Flexible Ion Sources: Compatible with Agilent Jet Stream ESI, APCI, and multimode ion sources for diverse workflows.
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Scalable Platform: Suitable for standalone use or integration into automated high-throughput LC-MS workflows.
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MassHunter Software Suite: Comprehensive quantitation, method development, and compliance-ready reporting.
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Regulatory Compliance: 21 CFR Part 11 support for GMP/GLP laboratories.
Applications:
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Pharmaceutical & Clinical Research: Quantitative drug metabolism, pharmacokinetics (DMPK), bioanalysis, and biomarker validation.
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Food Safety Testing: Quantitation of pesticide residues, veterinary drugs, contaminants, and mycotoxins.
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Environmental Monitoring: Trace-level detection of pollutants, emerging contaminants, and pharmaceuticals in water and soil.
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Forensics & Toxicology: Quantitative analysis of drugs of abuse, forensic toxicants, and clinical toxicology studies.
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Proteomics & Biomarker Research: Targeted quantitation of peptides and proteins.
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Biopharmaceutical Development: Impurity profiling, process monitoring, and stability testing.
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Routine Quantitative Analysis: High-throughput, regulatory-compliant workflows across industries.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS System Type | Triple Quadrupole LC/MS (TQ) |
| Model | G6465B (Ultivo Triple Quadrupole) |
| Mass Range | m/z 10 – 3,000 |
| Mass Accuracy | Unit mass resolution (0.7 Da FWHM) |
| Ionization Modes | ESI with Jet Stream Technology, APCI, multimode sources |
| Polarity Switching | <20 ms |
| Acquisition Modes | MRM, dynamic MRM (dMRM), SIM |
| Dynamic Range | >5 orders of magnitude |
| Sensitivity (LOQ) | <1 fg on-column (typical for standard analytes) |
| Collision Cell | Linear collision cell (LCID) with axial acceleration |
| Acquisition Speed | Supports >500 MRM transitions/sec |
| Vacuum System | Turbo molecular pumps |
| Interface | Orthogonal ESI source with ion funnel optics |
| Autosampler Compatibility | Agilent 1290 Infinity II series and 1260 Infinity II UHPLC |
| Software | Agilent MassHunter (quantitative analysis, method development, compliance tools) |
| Compliance | 21 CFR Part 11 support for GLP/GMP labs |