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Agilent Ultivo Triple Quadrupole LC/MS System (G6465B)  compact, high-sensitivity LC-MS/MS instrument for targeted quantitation in pharmaceuticals, food safety, environmental analysis, forensics, and clinical research.

Key Features:

  • Ultra-Compact Design: One of the smallest triple quadrupole LC/MS systems available, reducing laboratory footprint while maintaining high performance.

  • High Sensitivity & Specificity: Optimized ion optics and collision cell design deliver superior limits of detection for trace-level quantitation.

  • Robust Quantitative Performance: Reliable, reproducible quantitation across complex sample matrices.

  • Fast Polarity Switching: <20 ms switching enables simultaneous detection of positive and negative ions within a single run.

  • Advanced Collision Cell: Linear collision cell (LCID) for efficient fragmentation and high signal-to-noise ratios.

  • High Data Acquisition Speed: Supports UHPLC peak widths with fast MRM (multiple reaction monitoring) transitions.

  • Ease of Use: Streamlined setup and reduced maintenance with accessible components and built-in diagnostics.

  • Flexible Ion Sources: Compatible with Agilent Jet Stream ESI, APCI, and multimode ion sources for diverse workflows.

  • Scalable Platform: Suitable for standalone use or integration into automated high-throughput LC-MS workflows.

  • MassHunter Software Suite: Comprehensive quantitation, method development, and compliance-ready reporting.

  • Regulatory Compliance: 21 CFR Part 11 support for GMP/GLP laboratories.


Applications:

  • Pharmaceutical & Clinical Research: Quantitative drug metabolism, pharmacokinetics (DMPK), bioanalysis, and biomarker validation.

  • Food Safety Testing: Quantitation of pesticide residues, veterinary drugs, contaminants, and mycotoxins.

  • Environmental Monitoring: Trace-level detection of pollutants, emerging contaminants, and pharmaceuticals in water and soil.

  • Forensics & Toxicology: Quantitative analysis of drugs of abuse, forensic toxicants, and clinical toxicology studies.

  • Proteomics & Biomarker Research: Targeted quantitation of peptides and proteins.

  • Biopharmaceutical Development: Impurity profiling, process monitoring, and stability testing.

  • Routine Quantitative Analysis: High-throughput, regulatory-compliant workflows across industries.


Specifications (Table):

Parameter Specification
MS System Type Triple Quadrupole LC/MS (TQ)
Model G6465B (Ultivo Triple Quadrupole)
Mass Range m/z 10 – 3,000
Mass Accuracy Unit mass resolution (0.7 Da FWHM)
Ionization Modes ESI with Jet Stream Technology, APCI, multimode sources
Polarity Switching <20 ms
Acquisition Modes MRM, dynamic MRM (dMRM), SIM
Dynamic Range >5 orders of magnitude
Sensitivity (LOQ) <1 fg on-column (typical for standard analytes)
Collision Cell Linear collision cell (LCID) with axial acceleration
Acquisition Speed Supports >500 MRM transitions/sec
Vacuum System Turbo molecular pumps
Interface Orthogonal ESI source with ion funnel optics
Autosampler Compatibility Agilent 1290 Infinity II series and 1260 Infinity II UHPLC
Software Agilent MassHunter (quantitative analysis, method development, compliance tools)
Compliance 21 CFR Part 11 support for GLP/GMP labs


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