Skip to product information
Bruker timsTOF fleX MALDI-2 with Elute UHPLC hybrid 4D LC-QTOF/MS system combining ultra-high-resolution LC-MS/MS proteomics with MALDI-2 imaging for spatial omics, biomarker discovery, and pharmaceutical research.
  • Bruker timsTOF fleX MALDI-2 with Elute UHPLC hybrid 4D LC-QTOF/MS system combining ultra-high-resolution LC-MS/MS proteomics with MALDI-2 imaging for spatial omics, biomarker discovery, and pharmaceutical research.
  • Bruker timsTOF fleX MALDI-2 with Elute UHPLC hybrid 4D LC-QTOF/MS system combining ultra-high-resolution LC-MS/MS proteomics with MALDI-2 imaging for spatial omics, biomarker discovery, and pharmaceutical research.
Bruker timsTOF fleX MALDI-2 with Elute UHPLC Hybrid 4D LC-QTOF/MS
$0.00

Key Features:

  • Hybrid Dual-Mode Platform: Combines UHPLC-based LC-MS/MS with MALDI-2 imaging on a single instrument.

  • Elute UHPLC Integration: Provides ultra-high-performance chromatographic separation with robust reproducibility for proteomics and metabolomics.

  • MALDI-2 Post-Ionization: Enhances sensitivity and ion yield for lipids, metabolites, glycans, and peptides in imaging and LC workflows.

  • Trapped Ion Mobility Spectrometry (TIMS): Enables true 4D separation (retention time, m/z, ion mobility, intensity).

  • PASEF Technology: Ultra-fast acquisition for proteomics, enabling >100 Hz MS/MS speed.

  • High Resolution: >60,000 FWHM resolution and <1 ppm mass accuracy.

  • Flexible Workflows: Switch seamlessly between tissue imaging, LC-based proteomics, metabolomics, and drug analysis.

  • Regulatory Ready: 21 CFR Part 11 compliant for pharma and clinical labs.

Applications:

  • Proteomics & Metabolomics: High-throughput, deep proteome coverage with LC-PASEF workflows.

  • Spatial Omics Imaging: Enhanced molecular histology for lipids, metabolites, peptides, and proteins.

  • Drug Development & PK Studies: UHPLC-MS/MS drug quantification with imaging of compound distribution in tissues.

  • Biopharma R&D: Glycomics, lipidomics, and intact protein analysis.

  • Translational Medicine: Biomarker discovery and disease mapping directly in tissue context.

Specifications (Table):

Parameter Specification
MS Type Hybrid 4D TIMS-QTOF with dual-source (MALDI-2 + ESI)
LC System Bruker Elute UHPLC (nanoLC & capLC configurations)
Separation Mode UHPLC + TIMS ion mobility (4D separation)
Resolution >60,000 FWHM
Mass Accuracy <1 ppm (internal)
Acquisition Speed >100 Hz (with PASEF)
Mass Range m/z 20 – 20,000
Ionization Sources MALDI-2, CaptiveSpray nanoESI
Laser System Smartbeam™ 3D laser with MALDI-2 post-ionization
Sample Types LC-separated peptides/proteins, tissue sections, cell cultures, biofluids
Software Bruker ProteoScape, SCiLS Lab, Compass HyStar, MaxQuant
Compliance 21 CFR Part 11 ready
Key Advantage Combines LC-based proteomics with MALDI-2 imaging in a single system

 

You may also like