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Key Features:
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Hybrid High-Resolution System: Combines Bruker timsTOF Pro QTOF with the industry-leading Agilent 1290 Infinity II UHPLC for ultra-fast, high-efficiency separations.
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Trapped Ion Mobility Spectrometry (tims): Provides an orthogonal separation dimension, enabling 4D proteomics and resolving isomeric/structural variants.
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PASEF Technology: (Parallel Accumulation Serial Fragmentation) achieves >100 Hz acquisition speeds with no sensitivity loss.
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Ultra-Deep Proteome Coverage: Identifies thousands of proteins per run with high reproducibility.
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Agilent 1290 Infinity II LC Benefits: Delivers ultra-high-pressure capacity (up to 1300 bar), low dispersion, precise gradient formation, and robust autosampling.
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Quantitative Versatility: Supports label-free quantitation, DIA, PRM, and multiplexed labeling workflows.
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High Sensitivity & Dynamic Range: Detects low-abundance biomarkers in complex biological samples.
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Robust, Scalable Platform: Designed for 24/7 operation in pharmaceutical, clinical, and core proteomics facilities.
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Comprehensive Software Integration: Compatible with Bruker ProteoScape, PEAKS, MaxQuant, Spectronaut, and Agilent MassHunter software for LC control.
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Regulatory Compliance: Fully supports 21 CFR Part 11 and GxP workflows.
Applications:
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Proteomics & Biomarker Discovery: Comprehensive peptide and protein identification.
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Pharmaceutical R&D: Drug metabolism, PK/PD studies, and biotherapeutic characterization.
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Clinical Research: Precision medicine and large-cohort proteomic studies.
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Metabolomics & Lipidomics: Ion mobility-enhanced analysis of small molecules and lipids.
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Food & Environmental Testing: Sensitive detection of contaminants and toxins.
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Structural Biology: Protein folding and conformational studies via ion mobility separation.
Specifications (Table):
| Parameter | Specification |
|---|---|
| MS Type | Trapped Ion Mobility (tims) Quadrupole Time-of-Flight (QTOF) |
| Special Technology | PASEF (Parallel Accumulation Serial Fragmentation) |
| Mass Range | m/z 20 – 20,000 |
| Resolution | >60,000 FWHM |
| Mass Accuracy | <1 ppm (internal), <3 ppm (external) |
| Acquisition Speed | >100 Hz with PASEF |
| Dynamic Range | >5 orders of magnitude |
| Ion Mobility Range | 0.6–2.0 Vs/cm² (1/K₀) |
| Ionization Sources | CaptiveSpray nanoESI, ESI, APCI (optional) |
| LC System | Agilent 1290 Infinity II UHPLC (binary/quaternary pumps, autosampler, column oven, DAD) |
| LC Pressure Capacity | Up to 1300 bar |
| Vacuum System | Multi-stage turbo pumping system |
| Software | Bruker Compass HyStar, ProteoScape, PEAKS, MaxQuant, Spectronaut, Agilent MassHunter (LC control) |
| Compliance | 21 CFR Part 11 ready |
| Key Advantage | Integrated 4D LC-MS/MS system with tims ion mobility and PASEF speed coupled to Agilent UHPLC power |