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Bruker timsTOF SCP ultra-sensitive TIMS-QTOF mass spectrometer for single-cell and trace proteomics, enabling 4D high-resolution LC-MS/MS analysis with PASEF technology for biomarker discovery and systems biology.
  • Bruker timsTOF SCP ultra-sensitive TIMS-QTOF mass spectrometer for single-cell and trace proteomics, enabling 4D high-resolution LC-MS/MS analysis with PASEF technology for biomarker discovery and systems biology.
  • Bruker timsTOF SCP ultra-sensitive TIMS-QTOF mass spectrometer for single-cell and trace proteomics, enabling 4D high-resolution LC-MS/MS analysis with PASEF technology for biomarker discovery and systems biology.
Bruker timsTOF SCP Ultra-Sensitive TIMS-QTOF Mass Spectrometer for Trace Proteomics
$0.00

Key Features:

  • Single-Cell Proteomics (SCP): Engineered specifically for ultra-sensitive proteomic analysis down to the single-cell level.

  • Ultra-Low Sample Input: Optimized ion optics, source design, and sensitivity enhancements enable trace detection from picogram to nanogram protein amounts.

  • Trapped Ion Mobility Spectrometry (TIMS): Provides an additional separation dimension, enabling 4D proteomics (retention time, m/z, ion mobility, intensity).

  • PASEF Technology: Parallel Accumulation–Serial Fragmentation delivers >100 Hz MS/MS acquisition speed with minimal sample loss.

  • High Resolution: >60,000 FWHM and sub-ppm mass accuracy for accurate identification.

  • Optimized for Nanoflow LC: Seamlessly integrates with nanoLC systems for single-cell and limited-sample workflows.

  • Compact Footprint: Benchtop high-resolution QTOF with small lab space requirements.

Applications:

  • Single-Cell Proteomics: High-throughput analysis of individual cells for systems biology and precision medicine.

  • Trace Proteomics: Ultra-low abundance protein detection in scarce or precious samples.

  • Biomarker Discovery: Early-stage disease marker identification from low-input clinical samples.

  • Cancer Research: Proteomic heterogeneity profiling at single-cell resolution.

  • Drug Development: Pharmacodynamic and pharmacokinetic studies with limited biological material.

  • Neuroscience & Stem Cell Studies: Protein-level insights from rare or small populations of cells.

Specifications (Table):

Parameter Specification
MS Type Ultra-Sensitive TIMS-QTOF
Sensitivity Optimized for single-cell proteomics (low picogram detection)
Resolution >60,000 FWHM
Mass Accuracy <1 ppm (internal calibration)
Acquisition Speed >100 Hz (with PASEF)
Mass Range m/z 20 – 20,000
Ion Mobility TIMS separation (4D proteomics)
Sample Input Compatible with nanoLC for ultra-low injection amounts
Software Bruker ProteoScape, MaxQuant, PEAKS, Compass HyStar
Footprint Benchtop system
Key Advantage Specifically designed for single-cell and ultra-trace proteomics

 

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