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Bruker timsTOF Ultra 2 with Evosep One LC – high-throughput 4D TIMS-QTOF proteomics LC-MS/MS system for large-scale biomarker discovery, single-cell proteomics, and precision medicine.
  • Bruker timsTOF Ultra 2 with Evosep One LC – high-throughput 4D TIMS-QTOF proteomics LC-MS/MS system for large-scale biomarker discovery, single-cell proteomics, and precision medicine.
  • Bruker timsTOF Ultra 2 with Evosep One LC – high-throughput 4D TIMS-QTOF proteomics LC-MS/MS system for large-scale biomarker discovery, single-cell proteomics, and precision medicine.
Bruker timsTOF Ultra 2 with Evosep One LC High-Throughput 4D Proteomics LC-MS/MS System
$0.00

Key Features:

  • Integrated High-Throughput LC-MS/MS: Combines the timsTOF Ultra 2 mass spectrometer with the Evosep One LC system for unmatched throughput in large-scale proteomics studies.

  • Evosep One Technology: Designed for clinical proteomics, enabling hundreds of samples per day with ultra-stable gradients and low carryover.

  • Ultra-Sensitive Mass Spectrometer: timsTOF Ultra 2 provides 4D proteomics (RT, m/z, ion mobility, intensity) with TIMS ion mobility separation.

  • PASEF for Speed: Parallel Accumulation–Serial Fragmentation acquisition delivering >120 Hz MS/MS while preserving sensitivity.

  • Reproducibility at Scale: Robust LC-MS/MS system tailored for cohort-scale biomarker discovery and translational proteomics.

  • Compact, Lab-Ready System: Streamlined footprint, engineered for routine high-throughput operation.

  • End-to-End Workflow Compatibility: Fully integrates with MaxQuant, PEAKS, ProteoScape, Spectronaut, and other proteomics bioinformatics tools.

Applications:

  • High-Throughput Clinical Proteomics: Designed for population-scale studies requiring consistent results across hundreds/thousands of samples.

  • Biomarker Discovery & Validation: Robust workflow for large sample cohorts in translational medicine.

  • Single-Cell & Low-Input Proteomics: Retains sensitivity for ultra-low sample analysis, while supporting throughput.

  • Pharmaceutical Development: Large-scale proteomics for biomarker verification, drug target analysis, and PK/PD studies.

  • Systems Biology & Precision Medicine: Deep proteomic coverage for large-cohort stratification studies.

  • Quality Control & Routine Proteomics: Enables standardized proteomic analysis pipelines for diagnostic research.

Specifications (Table):

Parameter Specification
MS Type TIMS-QTOF (Trapped Ion Mobility Quadrupole TOF)
UHPLC System Evosep One LC
Throughput Up to 300 samples/day (depending on workflow)
Resolution >60,000 FWHM
Mass Accuracy <1 ppm (internal calibration)
Mass Range m/z 20 – 20,000
Acquisition Speed >120 Hz MS/MS with PASEF
Dynamic Range >5 orders of magnitude
Ion Mobility TIMS – 4D separation
LC Flow Rates Nano- to microflow optimized
Autosampler Integrated with Evosep One, pre-set method-based workflows
Software Bruker ProteoScape, MaxQuant, PEAKS, Spectronaut
Compliance Supports 21 CFR Part 11
Key Advantage High-throughput 4D proteomics platform for clinical and large-cohort studies

 

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