The Cytiva ÄKTA Flux 6 is a versatile pilot-scale tangential flow filtration (TFF) system, designed for ultrafiltration (UF) and diafiltration (DF) processes. Built for process development and small-scale manufacturing, it allows researchers to concentrate, buffer-exchange, and clarify proteins, antibodies, and nucleic acids with high reproducibility. Its modular design and scalability make it an excellent choice for bridging laboratory methods to large-scale production.

Key Features

• Pilot-Scale UF/DF System: Handles volumes from 2 L up to ~20 L, making it suitable for process development and pilot production.

• Precise Process Control: Equipped with automated pressure, flow, and weight monitoring for reproducible operation.

• Flexible Filter Compatibility: Supports hollow fiber cartridges and filter cassettes for both microfiltration and ultrafiltration.

• Integrated Weighing System: Ensures accurate monitoring of retentate and permeate volumes.

• Data Management: USB and software connectivity enable run data export and batch documentation.

• Ease of Scale-Up: Method development at pilot scale can be directly transferred to larger ÄKTA Flux or manufacturing systems.

Applications

• Protein and Antibody Concentration – Concentrate biomolecules with minimal loss.

• Buffer Exchange & Diafiltration – Replace buffer systems efficiently for downstream processes.

• Process Development – Optimize ultrafiltration/diafiltration conditions before scale-up.

• Vaccine & Nucleic Acid Purification – Supports purification of DNA, RNA, and viral vectors.

• Biopharmaceutical Pilot Production – Ideal for pilot-scale manufacturing environments.

Specifications