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SCIEX 6500+ Triple Quad LC-MS/MS with Agilent 1290 Infinity II UHPLC Advanced Quantitative LC-MS/MS

Key Features:

  • Advanced Quantitative Performance: SCIEX 6500+ delivers sub-femtogram detection limits with exceptional quantitative accuracy for the most demanding assays.

  • Agilent 1290 Infinity II UHPLC: Provides ultra-high resolution chromatography with up to 1,200 bar pressure, ensuring sharper peaks, reproducibility, and robust sample throughput.

  • Turbo V™ and OptiFlow® Source: Supports both high-flow and microflow LC workflows, maximizing sensitivity and flexibility.

  • SelexION® Differential Ion Mobility (optional): Adds an orthogonal separation dimension to resolve isobaric interferences.

  • Ultra-Fast Polarity Switching: Less than 5 ms for efficient positive/negative ion monitoring in a single run.

  • High-Speed Acquisition: Up to 5,000 MRM transitions/sec for multiplexed assays without loss of data quality.

  • Wide Dynamic Range: Covers 6+ orders of magnitude for simultaneous quantification of trace-level and abundant analytes.

  • Robust Collision Cell: LINAC® technology minimizes crosstalk, improving reproducibility in complex biological matrices.

  • Regulatory Compliance: Compatible with 21 CFR Part 11 and suitable for GLP/GMP environments.

  • Software Integration: SCIEX OS and Analyst® software for compliant, automated workflows with efficient data review and reporting.


Applications:

  • Pharmaceutical & Biopharma: Bioanalytical quantitation, pharmacokinetics, DMPK studies, and impurity analysis.

  • Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and clinical pharmacology.

  • CRO Bioanalysis: High-throughput targeted quantitation for regulated drug development programs.

  • Food Safety & Agriculture: Detection of pesticides, mycotoxins, veterinary residues, and contaminants at ultra-trace levels.

  • Environmental Testing: Quantitative monitoring of pollutants, pharmaceuticals, and emerging contaminants.

  • Targeted Omics: Highly sensitive metabolomics and lipidomics workflows.


Specifications (Table):

Parameter Specification
MS Type Triple Quadrupole LC-MS/MS
Mass Range m/z 5 – 2,000
Resolution Unit resolution (0.7 Da FWHM)
Polarity Switching <5 ms
Dynamic Range >6 orders of magnitude
MRM Transitions Up to 5,000 transitions/sec
Acquisition Modes MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan
Ionization Sources Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI
SelexION® Technology Optional – Differential Ion Mobility
Collision Cell LINAC® collision cell
Vacuum System Dual turbomolecular pumps
UHPLC System Agilent 1290 Infinity II UHPLC
UHPLC Pressure Up to 1,200 bar
Flow Rate Range 0.001 – 5.0 mL/min
Column Temperature 10 – 100 °C
Autosampler High-capacity, ultra-low carryover (Agilent 1290)
Software Analyst®, SCIEX OS
Compliance 21 CFR Part 11, GLP/GMP ready


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