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Key Features:
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Advanced Quantitative Performance: SCIEX 6500+ delivers sub-femtogram detection limits with exceptional quantitative accuracy for the most demanding assays.
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Agilent 1290 Infinity II UHPLC: Provides ultra-high resolution chromatography with up to 1,200 bar pressure, ensuring sharper peaks, reproducibility, and robust sample throughput.
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Turbo V™ and OptiFlow® Source: Supports both high-flow and microflow LC workflows, maximizing sensitivity and flexibility.
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SelexION® Differential Ion Mobility (optional): Adds an orthogonal separation dimension to resolve isobaric interferences.
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Ultra-Fast Polarity Switching: Less than 5 ms for efficient positive/negative ion monitoring in a single run.
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High-Speed Acquisition: Up to 5,000 MRM transitions/sec for multiplexed assays without loss of data quality.
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Wide Dynamic Range: Covers 6+ orders of magnitude for simultaneous quantification of trace-level and abundant analytes.
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Robust Collision Cell: LINAC® technology minimizes crosstalk, improving reproducibility in complex biological matrices.
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Regulatory Compliance: Compatible with 21 CFR Part 11 and suitable for GLP/GMP environments.
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Software Integration: SCIEX OS and Analyst® software for compliant, automated workflows with efficient data review and reporting.
Applications:
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Pharmaceutical & Biopharma: Bioanalytical quantitation, pharmacokinetics, DMPK studies, and impurity analysis.
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Clinical & Forensic Research: Therapeutic drug monitoring, forensic toxicology, and clinical pharmacology.
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CRO Bioanalysis: High-throughput targeted quantitation for regulated drug development programs.
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Food Safety & Agriculture: Detection of pesticides, mycotoxins, veterinary residues, and contaminants at ultra-trace levels.
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Environmental Testing: Quantitative monitoring of pollutants, pharmaceuticals, and emerging contaminants.
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Targeted Omics: Highly sensitive metabolomics and lipidomics workflows.
Specifications (Table):
Parameter | Specification |
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MS Type | Triple Quadrupole LC-MS/MS |
Mass Range | m/z 5 – 2,000 |
Resolution | Unit resolution (0.7 Da FWHM) |
Polarity Switching | <5 ms |
Dynamic Range | >6 orders of magnitude |
MRM Transitions | Up to 5,000 transitions/sec |
Acquisition Modes | MRM, Product Ion, Precursor Ion, Neutral Loss, Full Scan |
Ionization Sources | Turbo V™, OptiFlow® Turbo V, DuoSpray®, APCI |
SelexION® Technology | Optional – Differential Ion Mobility |
Collision Cell | LINAC® collision cell |
Vacuum System | Dual turbomolecular pumps |
UHPLC System | Agilent 1290 Infinity II UHPLC |
UHPLC Pressure | Up to 1,200 bar |
Flow Rate Range | 0.001 – 5.0 mL/min |
Column Temperature | 10 – 100 °C |
Autosampler | High-capacity, ultra-low carryover (Agilent 1290) |
Software | Analyst®, SCIEX OS |
Compliance | 21 CFR Part 11, GLP/GMP ready |