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Key Features:
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Hybrid QTRAP Design: Combines triple quadrupole quantitation with linear ion trap (LIT) scanning for both targeted and qualitative workflows.
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Enhanced Quantitation: Sensitive and robust MRM transitions for trace-level quantitation in complex matrices.
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Linear Ion Trap Mode: Enables MS/MS/MS (MS³) scans, enhanced product ion (EPI) scanning, and qualitative structural elucidation.
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Shimadzu Nexera UHPLC Front-End: Provides ultra-fast gradients, high-pressure capability (up to 1300 bar), and excellent peak capacity for high-resolution separations.
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Dynamic MRM Capability: Flexibility for large panels of analytes without compromising data quality.
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Wide Dynamic Range: Reliable quantitation across 4–5 orders of magnitude.
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Polarity Switching: Rapid positive/negative switching for comprehensive analysis in a single run.
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Compact, Cost-Effective Platform: Affordable entry-level QTRAP solution with powerful quantitation and qualitative workflows.
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Software Ecosystem: SCIEX Analyst® software for acquisition, quantitation, and compliance-ready reporting.
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Regulatory Support: 21 CFR Part 11 compliance features for GLP/GMP-regulated environments.
Applications:
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Pharmaceutical/Biopharma: Drug discovery, drug metabolism (DMPK), pharmacokinetics (PK), and impurity profiling.
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Food Safety: Detection of pesticides, mycotoxins, contaminants, and veterinary drug residues.
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Environmental Testing: Monitoring pollutants, industrial chemicals, and pharmaceuticals in soil and water.
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Clinical & Forensic Toxicology: Drug screening, forensic toxicology, and biomarker quantitation.
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Metabolomics: Targeted metabolite identification and quantitation with enhanced product ion scanning.
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Academic & Research Labs: Structural elucidation with MS³ and flexible qualitative/quantitative workflows.
Specifications (Table):
| Parameter | Specification |
|---|---|
| System Configuration | SCIEX QTRAP 3200 LC-MS/MS with Shimadzu Nexera UHPLC |
| MS Type | Hybrid Triple Quadrupole – Linear Ion Trap (QTRAP) |
| Mass Range | m/z 5 – 2000 |
| Resolution | Unit mass resolution (0.7 Da FWHM) |
| Dynamic Range | 4–5 orders of magnitude |
| Ionization Modes | Turbo V™ source with ESI, APCI options |
| Polarity Switching | <50 ms |
| Acquisition Modes | MRM, SIM, Enhanced Product Ion (EPI), MS³, Precursor Ion Scan, Neutral Loss Scan |
| MRM Transition Speed | Up to 300 transitions/sec |
| Sensitivity (LOQ) | Low pg to fg level detection (compound dependent) |
| Collision Cell | Q2 linear collision cell |
| Vacuum System | Turbo molecular pumping system |
| UHPLC System | Shimadzu Nexera UHPLC (high-pressure, fast-gradient, up to 1300 bar) |
| Autosampler | Nexera autosampler with high-precision injection |
| Interface | Turbo V ion source with orthogonal spray design |
| Software | SCIEX Analyst® software suite |
| Compliance | 21 CFR Part 11, GLP/GMP ready |