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SCIEX QTRAP 3200 LC-MS/MS with Shimadzu Nexera UHPLC  hybrid triple quadrupole linear ion trap system for targeted quantitation, qualitative analysis, and regulated workflows in pharma, food safety, environmental, and clinical research.

Key Features:

  • Hybrid QTRAP Design: Combines triple quadrupole quantitation with linear ion trap (LIT) scanning for both targeted and qualitative workflows.

  • Enhanced Quantitation: Sensitive and robust MRM transitions for trace-level quantitation in complex matrices.

  • Linear Ion Trap Mode: Enables MS/MS/MS (MS³) scans, enhanced product ion (EPI) scanning, and qualitative structural elucidation.

  • Shimadzu Nexera UHPLC Front-End: Provides ultra-fast gradients, high-pressure capability (up to 1300 bar), and excellent peak capacity for high-resolution separations.

  • Dynamic MRM Capability: Flexibility for large panels of analytes without compromising data quality.

  • Wide Dynamic Range: Reliable quantitation across 4–5 orders of magnitude.

  • Polarity Switching: Rapid positive/negative switching for comprehensive analysis in a single run.

  • Compact, Cost-Effective Platform: Affordable entry-level QTRAP solution with powerful quantitation and qualitative workflows.

  • Software Ecosystem: SCIEX Analyst® software for acquisition, quantitation, and compliance-ready reporting.

  • Regulatory Support: 21 CFR Part 11 compliance features for GLP/GMP-regulated environments.


Applications:

  • Pharmaceutical/Biopharma: Drug discovery, drug metabolism (DMPK), pharmacokinetics (PK), and impurity profiling.

  • Food Safety: Detection of pesticides, mycotoxins, contaminants, and veterinary drug residues.

  • Environmental Testing: Monitoring pollutants, industrial chemicals, and pharmaceuticals in soil and water.

  • Clinical & Forensic Toxicology: Drug screening, forensic toxicology, and biomarker quantitation.

  • Metabolomics: Targeted metabolite identification and quantitation with enhanced product ion scanning.

  • Academic & Research Labs: Structural elucidation with MS³ and flexible qualitative/quantitative workflows.


Specifications (Table):

Parameter Specification
System Configuration SCIEX QTRAP 3200 LC-MS/MS with Shimadzu Nexera UHPLC
MS Type Hybrid Triple Quadrupole – Linear Ion Trap (QTRAP)
Mass Range m/z 5 – 2000
Resolution Unit mass resolution (0.7 Da FWHM)
Dynamic Range 4–5 orders of magnitude
Ionization Modes Turbo V™ source with ESI, APCI options
Polarity Switching <50 ms
Acquisition Modes MRM, SIM, Enhanced Product Ion (EPI), MS³, Precursor Ion Scan, Neutral Loss Scan
MRM Transition Speed Up to 300 transitions/sec
Sensitivity (LOQ) Low pg to fg level detection (compound dependent)
Collision Cell Q2 linear collision cell
Vacuum System Turbo molecular pumping system
UHPLC System Shimadzu Nexera UHPLC (high-pressure, fast-gradient, up to 1300 bar)
Autosampler Nexera autosampler with high-precision injection
Interface Turbo V ion source with orthogonal spray design
Software SCIEX Analyst® software suite
Compliance 21 CFR Part 11, GLP/GMP ready



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