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Key Features:
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Zeno Trap Technology: Provides up to 20× sensitivity gain by synchronizing ion pulses into the TOF analyzer, ensuring low-abundance ions are efficiently detected.
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Advanced UHPLC Front-End: Agilent 1290 Infinity II UHPLC delivers ultra-high resolution separations, precise gradients, and robust sample throughput for proteomics and metabolomics.
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High-Resolution Accurate Mass: >40,000 FWHM with sub-ppm mass accuracy for confident analyte identification.
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Fast Acquisition: >133 spectra/sec, supporting rapid UHPLC separations and high-throughput DIA workflows.
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Next-Generation SWATH DIA: Enhanced reproducibility and quantitative accuracy with improved sensitivity for complex sample analysis.
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Wide Dynamic Range: >5 orders of magnitude for detecting trace biomarkers alongside abundant species.
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Versatile Ionization: Turbo V™ and DuoSpray® sources support ESI and APCI workflows.
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Rapid Polarity Switching: <20 ms for dual polarity workflows without compromising cycle time.
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Optimized for Discovery & Quantitation: Ideal for both untargeted biomolecule profiling and targeted quantification.
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Regulatory Ready: Full GLP/GMP compatibility and 21 CFR Part 11 compliance for pharmaceutical and clinical environments.
Applications:
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Proteomics: Deep proteome coverage, biomarker discovery, quantitative SWATH DIA proteomics.
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Metabolomics & Lipidomics: Ultra-sensitive targeted and untargeted profiling of metabolites and lipids.
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Pharmaceutical R&D: Drug metabolism, pharmacokinetics, metabolite identification, impurity analysis, lead optimization.
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Clinical & Translational Research: Biomarker validation, disease pathway elucidation, and precision medicine applications.
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Food & Environmental Testing: High-resolution detection of pesticides, toxins, pollutants, and trace contaminants.
Specifications (Table):
| Parameter | Specification |
|---|---|
| System Configuration | SCIEX ZenoTOF 7600 LC-MS/MS + Agilent 1290 Infinity II UHPLC |
| MS Type | Hybrid Quadrupole-Time-of-Flight (Q-TOF) |
| Mass Range | m/z ~20 – 40,000 |
| Resolution | >40,000 FWHM |
| Mass Accuracy | <1 ppm with internal calibration |
| Dynamic Range | >5 orders of magnitude |
| Acquisition Speed | >133 spectra/sec |
| Ionization Modes | ESI, APCI |
| Polarity Switching | <20 ms |
| Acquisition Modes | Full Scan MS, IDA, SWATH DIA, Zeno MS/MS, MS/MSALL |
| Sensitivity | Up to 20× improved with Zeno Trap |
| Collision Cell | Q2 linear accelerator collision cell |
| Vacuum System | Differentially pumped turbo molecular pumps |
| UHPLC System | Agilent 1290 Infinity II UHPLC |
| Flow Rate Range | 0.001–5 mL/min |
| Gradient Precision | <0.07% RSD |
| Autosampler | Ultra-low carryover (<0.002%), precision injection |
| Interface | Turbo V™ Source, optional DuoSpray® |
| Software | SCIEX OS, DIA-NN integration |
| Compliance | 21 CFR Part 11, GLP/GMP ready |