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SCIEX ZenoTOF 7600 LC-MS/MS with Agilent 1290 Infinity II UHPLC advanced accurate mass QTOF system with Zeno trap technology for ultra-sensitive proteomics, metabolomics, pharmaceutical discovery, and translational research.

Key Features:

  • Zeno Trap Technology: Provides up to 20× sensitivity gain by synchronizing ion pulses into the TOF analyzer, ensuring low-abundance ions are efficiently detected.

  • Advanced UHPLC Front-End: Agilent 1290 Infinity II UHPLC delivers ultra-high resolution separations, precise gradients, and robust sample throughput for proteomics and metabolomics.

  • High-Resolution Accurate Mass: >40,000 FWHM with sub-ppm mass accuracy for confident analyte identification.

  • Fast Acquisition: >133 spectra/sec, supporting rapid UHPLC separations and high-throughput DIA workflows.

  • Next-Generation SWATH DIA: Enhanced reproducibility and quantitative accuracy with improved sensitivity for complex sample analysis.

  • Wide Dynamic Range: >5 orders of magnitude for detecting trace biomarkers alongside abundant species.

  • Versatile Ionization: Turbo V™ and DuoSpray® sources support ESI and APCI workflows.

  • Rapid Polarity Switching: <20 ms for dual polarity workflows without compromising cycle time.

  • Optimized for Discovery & Quantitation: Ideal for both untargeted biomolecule profiling and targeted quantification.

  • Regulatory Ready: Full GLP/GMP compatibility and 21 CFR Part 11 compliance for pharmaceutical and clinical environments.


Applications:

  • Proteomics: Deep proteome coverage, biomarker discovery, quantitative SWATH DIA proteomics.

  • Metabolomics & Lipidomics: Ultra-sensitive targeted and untargeted profiling of metabolites and lipids.

  • Pharmaceutical R&D: Drug metabolism, pharmacokinetics, metabolite identification, impurity analysis, lead optimization.

  • Clinical & Translational Research: Biomarker validation, disease pathway elucidation, and precision medicine applications.

  • Food & Environmental Testing: High-resolution detection of pesticides, toxins, pollutants, and trace contaminants.


Specifications (Table):

Parameter Specification
System Configuration SCIEX ZenoTOF 7600 LC-MS/MS + Agilent 1290 Infinity II UHPLC
MS Type Hybrid Quadrupole-Time-of-Flight (Q-TOF)
Mass Range m/z ~20 – 40,000
Resolution >40,000 FWHM
Mass Accuracy <1 ppm with internal calibration
Dynamic Range >5 orders of magnitude
Acquisition Speed >133 spectra/sec
Ionization Modes ESI, APCI
Polarity Switching <20 ms
Acquisition Modes Full Scan MS, IDA, SWATH DIA, Zeno MS/MS, MS/MSALL
Sensitivity Up to 20× improved with Zeno Trap
Collision Cell Q2 linear accelerator collision cell
Vacuum System Differentially pumped turbo molecular pumps
UHPLC System Agilent 1290 Infinity II UHPLC
Flow Rate Range 0.001–5 mL/min
Gradient Precision <0.07% RSD
Autosampler Ultra-low carryover (<0.002%), precision injection
Interface Turbo V™ Source, optional DuoSpray®
Software SCIEX OS, DIA-NN integration
Compliance 21 CFR Part 11, GLP/GMP ready


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