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Shimadzu LCMS-8045 Triple Quadrupole LC/MS  robust, high-sensitivity LC-MS/MS system for routine quantitative analysis in pharmaceutical, food safety, environmental, forensic, and clinical laboratories.
  • Key Features:

    • Balanced performance system designed for routine quantitative LC-MS/MS workflows across pharmaceuticals, food safety, clinical, and environmental applications.

    • Incorporates Shimadzu’s UFsweeper™ collision cell technology, enabling fast collision-induced dissociation with minimized ion losses.

    • Polarity switching of 30 msec, supporting rapid detection of both positive and negative ions.

    • Fast MRM acquisition capability (up to 500 transitions/sec) for simultaneous analysis of multiple analytes.

    • High sensitivity and selectivity with robust ion optics and heated ESI/APCI ion sources.

    • Dynamic range ≥ 5 orders of magnitude, allowing trace detection to high-abundance compound quantitation in the same run.

    • Designed for reliability and stability, with simplified maintenance and extended uptime for routine laboratories.

    • Fully compatible with Shimadzu Nexera UHPLC/Prominence LC platforms for enhanced chromatographic performance.

    • Seamlessly integrated with LabSolutions software, providing full control, data analysis, reporting, and compliance management.

    • Supports GLP/GMP and 21 CFR Part 11 electronic record requirements.

  • Applications:

    • Pharmaceutical & Biopharma: Drug discovery, DMPK, bioequivalence studies, impurity profiling, metabolite monitoring.

    • Food Safety & Agriculture: Quantitative detection of pesticide residues, mycotoxins, additives, veterinary drug residues.

    • Environmental Monitoring: Analysis of water, soil, and air contaminants, PPCPs (pharmaceuticals and personal care products).

    • Forensics & Toxicology: Drug screening, toxicological analysis, forensic casework, doping control.

    • Clinical Research & Diagnostics: Therapeutic drug monitoring (TDM), biomarker quantitation, targeted metabolomics.

    • Industrial & Specialty Chemicals: Quality assurance and quality control (QA/QC) of formulations and raw materials.

    • Academic & Government Labs: Advanced targeted quantitation in multi-disciplinary research settings.

  • Specifications:

Parameter Specification
System Type Triple Quadrupole LC-MS/MS
Ionization Sources ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization)
Mass Range m/z 2–2,000 (application dependent)
Scan Modes MRM, SIM, Product Ion Scan, Precursor Ion Scan, Neutral Loss Scan
Scan Speed Up to 30,000 u/sec
Polarity Switching 30 msec
MRM Capability Up to 500 transitions/sec
Collision Cell UFsweeper™ technology for efficient CID and minimal ion loss
Dynamic Range ≥ 5 orders of magnitude
Sensitivity High femtogram-level sensitivity
Vacuum System High-capacity turbomolecular pumps
LC Compatibility Nexera UHPLC, Prominence LC platforms
Software LabSolutions LCMS – integrated LC-MS control, data handling, compliance tools
Compliance GLP/GMP, 21 CFR Part 11


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