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Shimadzu LCMS-8050 Triple Quadrupole LC/MS  high-sensitivity mass spectrometer with femtogram-level detection and ultra-fast quantitative performance for pharmaceutical, food safety, environmental, forensic, and clinical research applications.
  • Key Features:

    • Ultra-high sensitivity triple quadrupole LC-MS/MS system designed for advanced quantitative workflows requiring femtogram-level detection.

    • Equipped with UFsweeper™ III collision cell technology, enabling high-efficiency CID with virtually no ion loss.

    • Polarity switching speed of 5 msec – among the fastest available – enabling near-simultaneous detection of positive and negative ions in one run.

    • Ultra-fast MRM capability (up to 555 transitions/sec) for high-throughput multi-analyte quantitation.

    • Scan speed of 30,000 u/sec for rapid and accurate data acquisition.

    • Robust ion source options (ESI, APCI, DUIS) optimized for high sensitivity and broad application coverage.

    • Wide linear dynamic range of ≥ 6 orders of magnitude, supporting both trace-level detection and high-concentration quantitation.

    • Compatible with Shimadzu Nexera UHPLC series, ensuring high chromatographic resolution with sub-2 µm particle performance.

    • Full integration with LabSolutions LCMS software for advanced data processing, automation, compliance, and customizable reporting.

    • Built for ruggedness and 24/7 operation, reducing downtime in high-throughput research and regulated labs.

    • Compliant with GLP/GMP and 21 CFR Part 11 standards.

  • Applications:

    • Pharmaceutical & Biopharma: PK/PD studies, DMPK workflows, metabolite ID, bioequivalence testing, trace impurity profiling.

    • Food Safety & Agriculture: Multi-residue pesticide screening, mycotoxin detection, veterinary drug residues, food additive and contaminant analysis.

    • Environmental Testing: Trace organic pollutants, endocrine disruptors, PPCPs, herbicides, pesticides, water/soil contamination studies.

    • Forensics & Toxicology: Drug screening, doping control, forensic toxicology investigations, controlled substance quantification.

    • Clinical Research: Targeted metabolomics, biomarker validation, therapeutic drug monitoring (TDM).

    • Industrial Chemicals: Quality control of fine chemicals, polymers, and specialty formulations.

    • Academic & Core Labs: Advanced multi-analyte quantitation for collaborative and interdisciplinary research.

  • Specifications:

Parameter Specification
System Type Triple Quadrupole LC-MS/MS
Ionization Sources ESI, APCI, DUIS (Dual Ion Source)
Mass Range m/z 2–2,000 (expandable with options)
Scan Modes MRM, SIM, Product Ion, Precursor Ion, Neutral Loss
Scan Speed Up to 30,000 u/sec
Polarity Switching 5 msec (ultra-fast)
MRM Capability Up to 555 transitions/sec
Collision Cell UFsweeper™ III collision cell, high-efficiency CID with minimal ion loss
Dynamic Range ≥ 6 orders of magnitude
Sensitivity Femtogram-level detection
Vacuum System High-performance turbomolecular pump system
LC Compatibility Nexera UHPLC, Prominence UFLC
Software LabSolutions LCMS – integrated LC/MS control, compliance, automation
Compliance GLP/GMP, 21 CFR Part 11


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