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Shimadzu LCMS-8060 Triple Quadrupole LC/MS with Nexera X2 UHPLC  ultra-sensitive, high-performance UHPLC-MS/MS system for pharmaceutical, food safety, environmental, forensic, and clinical applications.
  • Key Features:

    • Integrated platform combining the Shimadzu LCMS-8060 triple quadrupole mass spectrometer with the Nexera X2 UHPLC system for maximum sensitivity, speed, and reproducibility.

    • Nexera X2 UHPLC delivers ultra-high-pressure solvent delivery, high-resolution separations with sub-2 µm particle compatibility, and rapid gradient switching for robust chromatography.

    • UF-Qarray™ ion optics enhance ion transmission, improving signal-to-noise and enabling femtogram-level sensitivity.

    • UFsweeper™ III collision cell ensures ultra-efficient CID with minimal ion loss, improving quantitative accuracy.

    • Polarity switching in 5 msec, enabling simultaneous detection of positive and negative ions within a single injection.

    • Ultra-fast MRM acquisition (up to 555 transitions/sec) with accurate dwell times for high-throughput multiplexed workflows.

    • Scan speed of 30,000 u/sec, ensuring rapid acquisition with uncompromised data quality.

    • Dynamic range exceeding 6 orders of magnitude, ensuring accurate quantitation across wide concentration ranges.

    • Nexera X2 autosampler with overlapping injection improves sample throughput, reducing idle time between analyses.

    • LabSolutions LCMS software offers complete control of LC and MS, powerful quantitation workflows, automated reporting, and 21 CFR Part 11 compliance for regulated labs.

    • Engineered for ruggedness and reliability, minimizing downtime and maintenance in high-throughput laboratories.

  • Applications:

    • Pharmaceutical & Biopharma: PK/PD studies, DMPK workflows, drug metabolism studies, impurity testing, targeted peptide/protein quantification, bioequivalence research.

    • Food Safety & Agriculture: Residue screening (pesticides, mycotoxins, veterinary drugs), food contaminants, additives, allergens.

    • Environmental Monitoring: Trace-level detection of PPCPs, pesticides, endocrine disruptors, herbicides, and pollutants in complex matrices.

    • Forensic & Toxicology: Forensic drug screening, doping control, toxicant detection, clinical toxicology workflows.

    • Clinical & Biomedical Research: Biomarker discovery, therapeutic drug monitoring, targeted metabolomics, validation of clinical assays.

    • Industrial & Specialty Chemicals: QA/QC of chemical formulations, raw material testing, trace impurity monitoring.

    • Academia & Core Research Facilities: Targeted omics (proteomics, metabolomics, lipidomics) with high sensitivity and throughput.

  • Specifications:

Parameter Specification
System Type Integrated UHPLC-Triple Quadrupole LC-MS/MS
UHPLC Platform Shimadzu Nexera X2 UHPLC
LC Features Sub-2 µm compatibility, high-pressure gradient delivery, ultra-fast solvent switching
Autosampler Nexera X2 autosampler with overlapping injection capability
Mass Analyzer Triple Quadrupole with UF-Qarray™ ion optics and UFsweeper™ III collision cell
Ionization Sources ESI, APCI, DUIS (Dual Ion Source)
Mass Range m/z 2–2,000 (expandable with options)
Scan Modes MRM, SIM, Product Ion, Precursor Ion, Neutral Loss
Scan Speed Up to 30,000 u/sec
Polarity Switching 5 msec (ultra-fast)
MRM Capability Up to 555 transitions/sec
Dynamic Range ≥ 6 orders of magnitude
Sensitivity Femtogram-level detection limits
Vacuum System High-performance turbomolecular pump system
Software LabSolutions LCMS – complete LC-MS control, automation, quantitation, compliance
Compliance GLP/GMP, 21 CFR Part 11


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