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Key Features:
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Integrated platform combining the Shimadzu LCMS-8060 triple quadrupole mass spectrometer with the Nexera X2 UHPLC system for maximum sensitivity, speed, and reproducibility.
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Nexera X2 UHPLC delivers ultra-high-pressure solvent delivery, high-resolution separations with sub-2 µm particle compatibility, and rapid gradient switching for robust chromatography.
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UF-Qarray™ ion optics enhance ion transmission, improving signal-to-noise and enabling femtogram-level sensitivity.
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UFsweeper™ III collision cell ensures ultra-efficient CID with minimal ion loss, improving quantitative accuracy.
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Polarity switching in 5 msec, enabling simultaneous detection of positive and negative ions within a single injection.
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Ultra-fast MRM acquisition (up to 555 transitions/sec) with accurate dwell times for high-throughput multiplexed workflows.
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Scan speed of 30,000 u/sec, ensuring rapid acquisition with uncompromised data quality.
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Dynamic range exceeding 6 orders of magnitude, ensuring accurate quantitation across wide concentration ranges.
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Nexera X2 autosampler with overlapping injection improves sample throughput, reducing idle time between analyses.
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LabSolutions LCMS software offers complete control of LC and MS, powerful quantitation workflows, automated reporting, and 21 CFR Part 11 compliance for regulated labs.
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Engineered for ruggedness and reliability, minimizing downtime and maintenance in high-throughput laboratories.
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Applications:
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Pharmaceutical & Biopharma: PK/PD studies, DMPK workflows, drug metabolism studies, impurity testing, targeted peptide/protein quantification, bioequivalence research.
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Food Safety & Agriculture: Residue screening (pesticides, mycotoxins, veterinary drugs), food contaminants, additives, allergens.
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Environmental Monitoring: Trace-level detection of PPCPs, pesticides, endocrine disruptors, herbicides, and pollutants in complex matrices.
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Forensic & Toxicology: Forensic drug screening, doping control, toxicant detection, clinical toxicology workflows.
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Clinical & Biomedical Research: Biomarker discovery, therapeutic drug monitoring, targeted metabolomics, validation of clinical assays.
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Industrial & Specialty Chemicals: QA/QC of chemical formulations, raw material testing, trace impurity monitoring.
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Academia & Core Research Facilities: Targeted omics (proteomics, metabolomics, lipidomics) with high sensitivity and throughput.
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Specifications:
Parameter | Specification |
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System Type | Integrated UHPLC-Triple Quadrupole LC-MS/MS |
UHPLC Platform | Shimadzu Nexera X2 UHPLC |
LC Features | Sub-2 µm compatibility, high-pressure gradient delivery, ultra-fast solvent switching |
Autosampler | Nexera X2 autosampler with overlapping injection capability |
Mass Analyzer | Triple Quadrupole with UF-Qarray™ ion optics and UFsweeper™ III collision cell |
Ionization Sources | ESI, APCI, DUIS (Dual Ion Source) |
Mass Range | m/z 2–2,000 (expandable with options) |
Scan Modes | MRM, SIM, Product Ion, Precursor Ion, Neutral Loss |
Scan Speed | Up to 30,000 u/sec |
Polarity Switching | 5 msec (ultra-fast) |
MRM Capability | Up to 555 transitions/sec |
Dynamic Range | ≥ 6 orders of magnitude |
Sensitivity | Femtogram-level detection limits |
Vacuum System | High-performance turbomolecular pump system |
Software | LabSolutions LCMS – complete LC-MS control, automation, quantitation, compliance |
Compliance | GLP/GMP, 21 CFR Part 11 |