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Key Features:
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Advanced Quadrupole Time-of-Flight (Q-TOF) mass spectrometer with true high-resolution and accurate-mass (HRAM) performance.
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Equipped with iRefTOF™ reflectron technology for long-term resolution stability and consistent mass accuracy.
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Industry-leading mass stability (<1 ppm over extended runs) without the need for frequent recalibration.
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High-speed polarity switching (<10 msec) allows simultaneous positive and negative ion analysis.
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Ultra-fast data acquisition rates (up to 100 spectra/sec) for comprehensive peak profiling.
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Exceptional dynamic range (>5 orders of magnitude) enabling quantification of trace-level and abundant compounds.
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Optimized for data-dependent acquisition (DDA), data-independent acquisition (DIA), SWATH®, and MRM-like workflows.
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Supports multiple ionization techniques (ESI, APCI, dual-source) for flexible application coverage.
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High-throughput compatibility with Shimadzu Nexera UHPLC/X2/XR systems or third-party LC modules.
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User-friendly LabSolutions™ software for complete system control, compliance, and integrated data analysis.
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Built for robustness with minimized maintenance requirements, maximizing uptime in high-demand labs.
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Full 21 CFR Part 11 compliance support for regulated pharmaceutical environments.
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Applications:
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Proteomics: Deep proteome coverage, biomarker discovery, post-translational modification (PTM) analysis, protein characterization.
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Metabolomics: Comprehensive metabolic profiling, biomarker validation, systems biology.
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Pharmaceutical Research: Drug discovery, lead optimization, pharmacokinetics, ADME, impurity profiling, metabolite identification.
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Clinical Research: Translational studies, biomarker verification, personalized medicine workflows.
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Food Safety: Contaminant screening, pesticide residue analysis, nutritional profiling.
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Environmental Testing: Detection of pollutants, trace organic compounds, and emerging contaminants.
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Forensics & Toxicology: Drug testing, forensic toxicology, anti-doping analysis.
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Biotechnology: Biotherapeutic characterization, glycomics, lipidomics.
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Academic & Government Research: Fundamental molecular science, omics-based investigations.
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Specifications:
Parameter | Specification |
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LC Platform | Compatible with Shimadzu Nexera X2/XR/XS UHPLC or third-party LC systems |
MS System Type | Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM) |
Ionization Modes | ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization), Dual-source capability, Positive/Negative polarity |
Scan Speed | Up to 100 spectra/sec |
Polarity Switching | <10 msec (positive/negative switching) |
Acquisition Modes | Full-scan MS, MS/MS, Data-Dependent Acquisition (DDA), Data-Independent Acquisition (DIA), SWATH®, Targeted MRM-like workflows |
Dynamic Range | >5 orders of magnitude |
Mass Accuracy | <1 ppm (internal calibration) |
Resolving Power | >40,000–50,000 FWHM |
Vacuum System | Multi-stage turbomolecular pump |
Autosampler | Compatible UHPLC autosampler (temperature-controlled, high-throughput) |
Interface | Heated ESI/APCI source with robust ion transfer efficiency |
Software | Shimadzu LabSolutions LCMS with compliance tools and data processing modules |
Compliance | 21 CFR Part 11 compatible for regulated environments |