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Shimadzu LCMS-9050 Q-TOF LC/MS High-Resolution Mass Spectrometer  advanced quadrupole time-of-flight system delivering accurate mass, high-resolution, and ultra-fast acquisition for proteomics, metabolomics, pharmaceutical, environmental, food safety, and clinical research.
  • Key Features:

    • Advanced Quadrupole Time-of-Flight (Q-TOF) mass spectrometer with true high-resolution and accurate-mass (HRAM) performance.

    • Equipped with iRefTOF™ reflectron technology for long-term resolution stability and consistent mass accuracy.

    • Industry-leading mass stability (<1 ppm over extended runs) without the need for frequent recalibration.

    • High-speed polarity switching (<10 msec) allows simultaneous positive and negative ion analysis.

    • Ultra-fast data acquisition rates (up to 100 spectra/sec) for comprehensive peak profiling.

    • Exceptional dynamic range (>5 orders of magnitude) enabling quantification of trace-level and abundant compounds.

    • Optimized for data-dependent acquisition (DDA), data-independent acquisition (DIA), SWATH®, and MRM-like workflows.

    • Supports multiple ionization techniques (ESI, APCI, dual-source) for flexible application coverage.

    • High-throughput compatibility with Shimadzu Nexera UHPLC/X2/XR systems or third-party LC modules.

    • User-friendly LabSolutions™ software for complete system control, compliance, and integrated data analysis.

    • Built for robustness with minimized maintenance requirements, maximizing uptime in high-demand labs.

    • Full 21 CFR Part 11 compliance support for regulated pharmaceutical environments.

  • Applications:

    • Proteomics: Deep proteome coverage, biomarker discovery, post-translational modification (PTM) analysis, protein characterization.

    • Metabolomics: Comprehensive metabolic profiling, biomarker validation, systems biology.

    • Pharmaceutical Research: Drug discovery, lead optimization, pharmacokinetics, ADME, impurity profiling, metabolite identification.

    • Clinical Research: Translational studies, biomarker verification, personalized medicine workflows.

    • Food Safety: Contaminant screening, pesticide residue analysis, nutritional profiling.

    • Environmental Testing: Detection of pollutants, trace organic compounds, and emerging contaminants.

    • Forensics & Toxicology: Drug testing, forensic toxicology, anti-doping analysis.

    • Biotechnology: Biotherapeutic characterization, glycomics, lipidomics.

    • Academic & Government Research: Fundamental molecular science, omics-based investigations.

  • Specifications:

Parameter Specification
LC Platform Compatible with Shimadzu Nexera X2/XR/XS UHPLC or third-party LC systems
MS System Type Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM)
Ionization Modes ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization), Dual-source capability, Positive/Negative polarity
Scan Speed Up to 100 spectra/sec
Polarity Switching <10 msec (positive/negative switching)
Acquisition Modes Full-scan MS, MS/MS, Data-Dependent Acquisition (DDA), Data-Independent Acquisition (DIA), SWATH®, Targeted MRM-like workflows
Dynamic Range >5 orders of magnitude
Mass Accuracy <1 ppm (internal calibration)
Resolving Power >40,000–50,000 FWHM
Vacuum System Multi-stage turbomolecular pump
Autosampler Compatible UHPLC autosampler (temperature-controlled, high-throughput)
Interface Heated ESI/APCI source with robust ion transfer efficiency
Software Shimadzu LabSolutions LCMS with compliance tools and data processing modules
Compliance 21 CFR Part 11 compatible for regulated environments


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