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Key Features:
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Combines the Shimadzu LCMS-9050 Q-TOF with Nexera X2 UHPLC for a fully integrated, high-resolution LC-MS/MS platform.
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iRefTOF™ reflectron technology ensures long-term resolution stability with consistently accurate mass measurement.
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Industry-leading mass stability (<1 ppm) reduces recalibration frequency, maximizing uptime in high-throughput labs.
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Nexera X2 UHPLC delivers ultra-high pressure operation with precise flow control for reproducible chromatographic separations.
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High-speed scan rate (up to 100 spectra/sec) with <10 msec polarity switching enables comprehensive sample profiling.
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Broad dynamic range (>5 orders of magnitude) supports trace-level and high-abundance analyte quantification in a single run.
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Multiple acquisition modes: DDA, DIA, SWATH®, full-scan, MS/MS, targeted MRM-like methods.
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Flexible ionization options: ESI, APCI, dual-source configurations for expanded application coverage.
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Seamless hardware–software integration with LabSolutions LCMS for full control of both LC and MS modules.
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Designed for regulated labs with 21 CFR Part 11 compliance and secure audit trail features.
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Robust design with minimal maintenance requirements, ideal for continuous operation in research and industrial environments.
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Applications:
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Proteomics: Large-scale biomarker discovery, protein PTM analysis, deep proteome coverage.
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Metabolomics: Comprehensive profiling, biomarker validation, pathway elucidation.
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Pharmaceutical Development: Drug discovery, lead optimization, ADME/Tox, impurity analysis, metabolite identification.
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Clinical Research: Translational medicine, personalized medicine, disease biomarker verification.
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Food Safety: Detection of pesticides, contaminants, additives, and nutritional compound profiling.
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Environmental Testing: Monitoring trace pollutants, persistent organic compounds, emerging contaminants.
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Forensics & Toxicology: Doping control, forensic toxicology, drug screening.
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Biotechnology: Biopharmaceutical characterization, glycomics, lipidomics.
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Academic & Government Labs: Advanced omics research, systems biology, molecular science.
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Specifications:
Parameter | Specification |
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LC Platform | Shimadzu Nexera X2 UHPLC with high-pressure gradient pumps, precise autosampler, temperature control |
MS System Type | Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM) |
Ionization Modes | ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization), Dual-source, Positive/Negative polarity |
Scan Speed | Up to 100 spectra/sec |
Polarity Switching | <10 msec (fast positive/negative switching) |
Acquisition Modes | Full-scan MS, MS/MS, DDA, DIA, SWATH®, Targeted workflows |
Dynamic Range | >5 orders of magnitude |
Mass Accuracy | <1 ppm (internal calibration) |
Resolving Power | >40,000–50,000 FWHM |
Vacuum System | Multi-stage turbomolecular pump |
Autosampler | Nexera X2 UHPLC autosampler with high-throughput and temperature control |
Interface | Heated ESI/APCI source with robust ion transmission |
Software | LabSolutions LCMS with integrated LC-MS/MS control and compliance functions |
Compliance | 21 CFR Part 11 compatible for regulated environments |