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Shimadzu LCMS-9050 Q-TOF LC/MS with Nexera X2 UHPLC  fully integrated high-resolution LC-MS/MS system combining advanced Q-TOF accurate mass spectrometry with UHPLC precision for proteomics, metabolomics, pharmaceutical, food safety, clinical, environmental, and forensic applications.
  • Key Features:

    • Combines the Shimadzu LCMS-9050 Q-TOF with Nexera X2 UHPLC for a fully integrated, high-resolution LC-MS/MS platform.

    • iRefTOF™ reflectron technology ensures long-term resolution stability with consistently accurate mass measurement.

    • Industry-leading mass stability (<1 ppm) reduces recalibration frequency, maximizing uptime in high-throughput labs.

    • Nexera X2 UHPLC delivers ultra-high pressure operation with precise flow control for reproducible chromatographic separations.

    • High-speed scan rate (up to 100 spectra/sec) with <10 msec polarity switching enables comprehensive sample profiling.

    • Broad dynamic range (>5 orders of magnitude) supports trace-level and high-abundance analyte quantification in a single run.

    • Multiple acquisition modes: DDA, DIA, SWATH®, full-scan, MS/MS, targeted MRM-like methods.

    • Flexible ionization options: ESI, APCI, dual-source configurations for expanded application coverage.

    • Seamless hardware–software integration with LabSolutions LCMS for full control of both LC and MS modules.

    • Designed for regulated labs with 21 CFR Part 11 compliance and secure audit trail features.

    • Robust design with minimal maintenance requirements, ideal for continuous operation in research and industrial environments.

  • Applications:

    • Proteomics: Large-scale biomarker discovery, protein PTM analysis, deep proteome coverage.

    • Metabolomics: Comprehensive profiling, biomarker validation, pathway elucidation.

    • Pharmaceutical Development: Drug discovery, lead optimization, ADME/Tox, impurity analysis, metabolite identification.

    • Clinical Research: Translational medicine, personalized medicine, disease biomarker verification.

    • Food Safety: Detection of pesticides, contaminants, additives, and nutritional compound profiling.

    • Environmental Testing: Monitoring trace pollutants, persistent organic compounds, emerging contaminants.

    • Forensics & Toxicology: Doping control, forensic toxicology, drug screening.

    • Biotechnology: Biopharmaceutical characterization, glycomics, lipidomics.

    • Academic & Government Labs: Advanced omics research, systems biology, molecular science.

  • Specifications:

Parameter Specification
LC Platform Shimadzu Nexera X2 UHPLC with high-pressure gradient pumps, precise autosampler, temperature control
MS System Type Quadrupole Time-of-Flight (Q-TOF), High-Resolution Accurate Mass (HRAM)
Ionization Modes ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization), Dual-source, Positive/Negative polarity
Scan Speed Up to 100 spectra/sec
Polarity Switching <10 msec (fast positive/negative switching)
Acquisition Modes Full-scan MS, MS/MS, DDA, DIA, SWATH®, Targeted workflows
Dynamic Range >5 orders of magnitude
Mass Accuracy <1 ppm (internal calibration)
Resolving Power >40,000–50,000 FWHM
Vacuum System Multi-stage turbomolecular pump
Autosampler Nexera X2 UHPLC autosampler with high-throughput and temperature control
Interface Heated ESI/APCI source with robust ion transmission
Software LabSolutions LCMS with integrated LC-MS/MS control and compliance functions
Compliance 21 CFR Part 11 compatible for regulated environments



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