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Key Features:
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High-sensitivity Triple Quadrupole LC-MS/MS system engineered for demanding quantitative workflows
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Coupled with UltiMate 3000 UHPLC for precise, reproducible, and high-throughput chromatographic separations
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S-Lens ion optics maximize ion transmission efficiency and improve overall sensitivity
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Fast polarity switching (<5 ms) enables simultaneous quantitation of diverse analytes in a single run
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Robust performance and durability, designed for long-term, high-sample-load environments
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Wide dynamic range (>5–6 orders of magnitude) for accurate trace detection and bulk quantification
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TraceFinder and Xcalibur software provide intuitive data acquisition, quantitation, and compliance features
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Applications:
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Pharmaceuticals: Bioequivalence studies, drug metabolism, impurity analysis
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Food Safety: Monitoring of pesticide residues, veterinary drug residues, and mycotoxins
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Environmental Testing: Analysis of pollutants, endocrine disruptors, and organic contaminants
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Clinical Research: Quantitative biomarker assays, therapeutic drug monitoring
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Forensics/Toxicology: Sensitive screening and quantitation of drugs and toxic substances
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | TSQ Vantage Triple Quadrupole LC-MS/MS with UltiMate 3000 UHPLC |
| MS System Type | Triple Quadrupole |
| Mass Range | m/z 10–2,000 |
| Ionization Modes | ESI (Electrospray Ionization), HESI (Heated Electrospray Ionization), APCI optional |
| Autosampler | UltiMate 3000 UHPLC autosampler with precise injection and temperature control |
| Acquisition Modes | Full Scan, SIM, MRM (Multiple Reaction Monitoring) |
| Dynamic Range | >5–6 orders of magnitude |
| Mass Accuracy | Unit mass resolution (Q1/Q3 quadrupoles) |
| Scan Speed | Up to ~500+ MRM transitions/sec |
| Vacuum System | Dual turbomolecular pumps with forepump |
| Interface | HESI-II heated electrospray source, optional APCI |
| Software | Thermo Scientific Xcalibur, TraceFinder, Chromeleon |
| Compliance | 21 CFR Part 11 compatible |