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Key Features:
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The Waters ACQUITY UPLC H-Class is a flexible quaternary UHPLC system, delivering high-resolution, reproducible separations with the versatility of quaternary solvent blending.
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Combines UPLC performance with the ease of HPLC method transfer, making it ideal for labs transitioning from conventional HPLC to UHPLC.
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Operates at pressures up to 15,000 psi (1034 bar), supporting sub-2 μm particle column technologies for sharper peaks and faster separations.
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Binary and quaternary solvent blending for complex gradient methods and broad application compatibility.
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High-precision autosampler with reduced carryover and fast cycle times for high-throughput workflows.
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Integrated column heater/cooler ensures reproducibility and stability.
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Compatible with a wide range of detectors: TUV (UV/Vis), PDA (Photodiode Array), FLR (Fluorescence), QDa Mass Detector.
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Full integration with Waters Empower CDS for data management, regulatory compliance, and audit trails.
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Compliant with GLP/GMP and 21 CFR Part 11, making it suitable for regulated pharmaceutical and biopharma labs.
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Applications:
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Pharmaceutical & Biopharmaceutical: Method development, assay, impurity profiling, bioanalytical studies, stability testing.
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Clinical Research & Omics: Proteomics, metabolomics, lipidomics, biomarker discovery.
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Food & Beverage: Analysis of vitamins, sweeteners, pesticides, contaminants, and additives.
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Environmental Testing: Trace detection of pollutants, pesticides, herbicides, and pharmaceuticals in water/soil.
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Forensic & Toxicology: Drug screening, toxicant identification, forensic compound analysis.
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Chemical Industry: Quality control of raw materials, fine chemicals, and intermediates.
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Academia/Research: Advanced chromatography training and multi-application research studies.
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Specifications:
Parameter | Specification |
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System Type | Ultra-High Performance Liquid Chromatography (UPLC) |
Pump | Quaternary or binary solvent delivery, flow rate 0.001–2 mL/min |
Max Pressure | Up to 15,000 psi (1034 bar) |
Autosampler | High-precision autosampler, injection volumes 0.1–10 µL, low carryover |
Column Oven | Temperature control from ambient +4 °C to 65 °C |
Detectors (options) | PDA (190–800 nm), TUV (UV/Vis), FLR (Fluorescence), QDa (Mass Detection) |
Resolution | Sub-2 µm particle compatibility for high resolution and fast separations |
Software | Waters Empower Chromatography Data System (CDS) |
Compliance | GLP/GMP, 21 CFR Part 11 compliant |