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Waters ACQUITY H-Class UPLC System  flexible quaternary UHPLC platform delivering high-resolution, reproducible chromatography for pharmaceutical, biopharma, food, environmental, forensic, and research laboratories.
  • Key Features:

    • The Waters ACQUITY UPLC H-Class is a flexible quaternary UHPLC system, delivering high-resolution, reproducible separations with the versatility of quaternary solvent blending.

    • Combines UPLC performance with the ease of HPLC method transfer, making it ideal for labs transitioning from conventional HPLC to UHPLC.

    • Operates at pressures up to 15,000 psi (1034 bar), supporting sub-2 μm particle column technologies for sharper peaks and faster separations.

    • Binary and quaternary solvent blending for complex gradient methods and broad application compatibility.

    • High-precision autosampler with reduced carryover and fast cycle times for high-throughput workflows.

    • Integrated column heater/cooler ensures reproducibility and stability.

    • Compatible with a wide range of detectors: TUV (UV/Vis), PDA (Photodiode Array), FLR (Fluorescence), QDa Mass Detector.

    • Full integration with Waters Empower CDS for data management, regulatory compliance, and audit trails.

    • Compliant with GLP/GMP and 21 CFR Part 11, making it suitable for regulated pharmaceutical and biopharma labs.

  • Applications:

    • Pharmaceutical & Biopharmaceutical: Method development, assay, impurity profiling, bioanalytical studies, stability testing.

    • Clinical Research & Omics: Proteomics, metabolomics, lipidomics, biomarker discovery.

    • Food & Beverage: Analysis of vitamins, sweeteners, pesticides, contaminants, and additives.

    • Environmental Testing: Trace detection of pollutants, pesticides, herbicides, and pharmaceuticals in water/soil.

    • Forensic & Toxicology: Drug screening, toxicant identification, forensic compound analysis.

    • Chemical Industry: Quality control of raw materials, fine chemicals, and intermediates.

    • Academia/Research: Advanced chromatography training and multi-application research studies.

  • Specifications:

Parameter Specification
System Type Ultra-High Performance Liquid Chromatography (UPLC)
Pump Quaternary or binary solvent delivery, flow rate 0.001–2 mL/min
Max Pressure Up to 15,000 psi (1034 bar)
Autosampler High-precision autosampler, injection volumes 0.1–10 µL, low carryover
Column Oven Temperature control from ambient +4 °C to 65 °C
Detectors (options) PDA (190–800 nm), TUV (UV/Vis), FLR (Fluorescence), QDa (Mass Detection)
Resolution Sub-2 µm particle compatibility for high resolution and fast separations
Software Waters Empower Chromatography Data System (CDS)
Compliance GLP/GMP, 21 CFR Part 11 compliant


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