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Key Features:
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Cyclic Ion Mobility Separation (cIMS) technology, enabling ions to pass through multiple cycles for enhanced resolution.
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Extended ion path length improves separation of isomers, conformers, and structural variants.
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High-resolution Q-TOF mass analyzer delivering accurate mass measurements across a wide m/z range.
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Integration with ACQUITY UPLC ensures sharp chromatographic peaks and reproducible separations.
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Compatible with multi-dimensional workflows combining LC, IMS, and MS for structural and functional analysis.
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Resolution up to 30,000 FWHM with mass accuracy better than 1 ppm.
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UNIFI and MassLynx software support streamlined data visualization, compliance, and reporting.
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Applications:
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Structural Biology: Conformational studies, protein folding, and complex assembly analysis.
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Proteomics: PTM characterization, structural isomer resolution, quantitative proteomics.
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Metabolomics/Lipidomics: Separation and identification of isobaric and conformationally distinct molecules.
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Biopharmaceuticals: Higher-order structure characterization, glycan profiling, intact protein analysis.
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Pharmaceutical Development: Drug metabolism, stability testing, structural elucidation.
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | Waters SELECT SERIES Cyclic IMS Q-TOF with ACQUITY UPLC |
| MS System Type | Quadrupole – Time-of-Flight with Cyclic Ion Mobility Separation |
| Mass Range | m/z 20–100,000 |
| Resolution | Up to 30,000 FWHM |
| Ionization Modes | ESI, NanoESI, APCI, APPI optional |
| Autosampler | ACQUITY UPLC autosampler |
| Acquisition Modes | MS, MS/MS, MSE, HDMSE, multi-pass ion mobility workflows |
| Dynamic Range | >4 orders of magnitude |
| Mass Accuracy | <1 ppm with lock-mass calibration |
| Vacuum System | Multi-stage turbomolecular pumping system |
| Interface | Z-Spray, NanoLockSpray ion source |
| Software | UNIFI, MassLynx, Progenesis QI |
| Compliance | 21 CFR Part 11 compatible |