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Waters SELECT SERIES Cyclic IMS Q-TOF LC-MS with ACQUITY UPLC advanced quadrupole time-of-flight mass spectrometer with cyclic ion mobility separation for proteomics, structural biology, pharmaceutical, and biopharmaceutical research
  • Key Features:

    • Cyclic Ion Mobility Separation (cIMS) technology, enabling ions to pass through multiple cycles for enhanced resolution.

    • Extended ion path length improves separation of isomers, conformers, and structural variants.

    • High-resolution Q-TOF mass analyzer delivering accurate mass measurements across a wide m/z range.

    • Integration with ACQUITY UPLC ensures sharp chromatographic peaks and reproducible separations.

    • Compatible with multi-dimensional workflows combining LC, IMS, and MS for structural and functional analysis.

    • Resolution up to 30,000 FWHM with mass accuracy better than 1 ppm.

    • UNIFI and MassLynx software support streamlined data visualization, compliance, and reporting.

  • Applications:

    • Structural Biology: Conformational studies, protein folding, and complex assembly analysis.

    • Proteomics: PTM characterization, structural isomer resolution, quantitative proteomics.

    • Metabolomics/Lipidomics: Separation and identification of isobaric and conformationally distinct molecules.

    • Biopharmaceuticals: Higher-order structure characterization, glycan profiling, intact protein analysis.

    • Pharmaceutical Development: Drug metabolism, stability testing, structural elucidation.

  • Specifications:

Specification Detail
LC/MS Platform Waters SELECT SERIES Cyclic IMS Q-TOF with ACQUITY UPLC
MS System Type Quadrupole – Time-of-Flight with Cyclic Ion Mobility Separation
Mass Range m/z 20–100,000
Resolution Up to 30,000 FWHM
Ionization Modes ESI, NanoESI, APCI, APPI optional
Autosampler ACQUITY UPLC autosampler
Acquisition Modes MS, MS/MS, MSE, HDMSE, multi-pass ion mobility workflows
Dynamic Range >4 orders of magnitude
Mass Accuracy <1 ppm with lock-mass calibration
Vacuum System Multi-stage turbomolecular pumping system
Interface Z-Spray, NanoLockSpray ion source
Software UNIFI, MassLynx, Progenesis QI
Compliance 21 CFR Part 11 compatible

 

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