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Key Features:
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Hybrid quadrupole time-of-flight (Q-TOF) architecture offering high-resolution, accurate-mass performance
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Coupled with ACQUITY M-Class UPLC, optimized for Nano- to micro-flow separations in proteomics and systems biology
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Ion mobility separation (IMS) provides orthogonal separation for isobaric and conformationally distinct species
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Resolution up to 40,000 FWHM for detailed molecular analysis and characterization
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MSE/HDMSE acquisition enables simultaneous qualitative and quantitative workflows
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Enhanced sensitivity for low-abundance peptides and metabolites in complex matrices
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Powered by UNIFI scientific information system for streamlined data processing and compliance
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Applications:
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Proteomics: NanoLC-based proteome profiling, PTM analysis, deep coverage workflows
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Metabolomics: High-resolution profiling of metabolites, biomarker discovery
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Biopharmaceuticals: Intact protein and peptide mapping, glycan analysis, structural biology
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Pharmaceuticals: Drug metabolism, impurity profiling, identification of degradation products
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Clinical Research: Translational biomarker studies, personalized medicine research
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | SYNAPT G2-Si Q-TOF LC-MS/MS with ACQUITY M-Class UPLC |
| MS System Type | Quadrupole – Time-of-Flight (Q-TOF) Hybrid |
| Mass Range | m/z 20–100,000 |
| Resolution | Up to 40,000 FWHM |
| Ionization Modes | NanoESI, ESI, APCI, APPI optional |
| Autosampler | ACQUITY M-Class UPLC with Nano- to micro-flow autosampler |
| Acquisition Modes | MS, MS/MS, MSE (data-independent), HDMSE (ion mobility-enabled) |
| Dynamic Range | >5 orders of magnitude |
| Mass Accuracy | <1 ppm with lock-mass calibration |
| Vacuum System | Multi-stage turbomolecular pumping |
| Interface | NanoLockSpray, Z-Spray ion source |
| Software | Waters UNIFI, MassLynx, Progenesis QI |
| Compliance | 21 CFR Part 11 compatible |