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Waters SYNAPT G2-Si Q-TOF LC-MS/MS with ACQUITY M-Class UPLC Nano- to micro-flow high-resolution hybrid mass spectrometry system for proteomics, metabolomics, pharmaceutical, and biopharmaceutical research
  • Key Features:

    • Hybrid quadrupole time-of-flight (Q-TOF) architecture offering high-resolution, accurate-mass performance

    • Coupled with ACQUITY M-Class UPLC, optimized for Nano- to micro-flow separations in proteomics and systems biology

    • Ion mobility separation (IMS) provides orthogonal separation for isobaric and conformationally distinct species

    • Resolution up to 40,000 FWHM for detailed molecular analysis and characterization

    • MSE/HDMSE acquisition enables simultaneous qualitative and quantitative workflows

    • Enhanced sensitivity for low-abundance peptides and metabolites in complex matrices

    • Powered by UNIFI scientific information system for streamlined data processing and compliance

  • Applications:

    • Proteomics: NanoLC-based proteome profiling, PTM analysis, deep coverage workflows

    • Metabolomics: High-resolution profiling of metabolites, biomarker discovery

    • Biopharmaceuticals: Intact protein and peptide mapping, glycan analysis, structural biology

    • Pharmaceuticals: Drug metabolism, impurity profiling, identification of degradation products

    • Clinical Research: Translational biomarker studies, personalized medicine research

  • Specifications:

Specification Detail
LC/MS Platform SYNAPT G2-Si Q-TOF LC-MS/MS with ACQUITY M-Class UPLC
MS System Type Quadrupole – Time-of-Flight (Q-TOF) Hybrid
Mass Range m/z 20–100,000
Resolution Up to 40,000 FWHM
Ionization Modes NanoESI, ESI, APCI, APPI optional
Autosampler ACQUITY M-Class UPLC with Nano- to micro-flow autosampler
Acquisition Modes MS, MS/MS, MSE (data-independent), HDMSE (ion mobility-enabled)
Dynamic Range >5 orders of magnitude
Mass Accuracy <1 ppm with lock-mass calibration
Vacuum System Multi-stage turbomolecular pumping
Interface NanoLockSpray, Z-Spray ion source
Software Waters UNIFI, MassLynx, Progenesis QI
Compliance 21 CFR Part 11 compatible

 

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