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Key Features:
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Integrated ion mobility separation (IMS) with high-resolution quadrupole TOF for multidimensional analysis.
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High-definition MSE (HDMSE) data-independent acquisition, delivering simultaneous qualitative and quantitative results.
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Resolution of up to 30,000 FWHM with <1 ppm mass accuracy.
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Enhanced selectivity and sensitivity for complex biological matrices.
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Compatible with ACQUITY UPLC systems for robust and reproducible separations.
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UNIFI scientific information system for compliance, data visualization, and biopharma-ready workflows.
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Simplified intact protein and biotherapeutic analysis with streamlined workflows.
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Applications:
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Proteomics: Biomarker discovery, PTM analysis, quantitative proteomics.
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Metabolomics/Lipidomics: Untargeted and targeted small molecule profiling.
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Biopharmaceuticals: Intact mass, peptide mapping, glycan profiling, structural analysis.
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Pharmaceuticals: Drug metabolism, impurity analysis, stability studies.
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Food Safety & Environmental: Trace-level contaminant detection, metabolite analysis.
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Specifications:
| Specification | Detail |
|---|---|
| LC/MS Platform | Waters Vion IMS Q-TOF LC-MS |
| MS System Type | Quadrupole – Time-of-Flight with Ion Mobility Separation |
| Mass Range | m/z 20–100,000 |
| Resolution | Up to 30,000 FWHM |
| Ionization Modes | ESI, NanoESI, APCI, APPI optional |
| Autosampler | Compatible with ACQUITY UPLC autosamplers |
| Acquisition Modes | MS, MS/MS, MSE, HDMSE (ion mobility-enabled) |
| Dynamic Range | >4 orders of magnitude |
| Mass Accuracy | <1 ppm with lock-mass calibration |
| Vacuum System | Multi-stage turbomolecular pumping |
| Interface | Z-Spray, NanoLockSpray ion source |
| Software | UNIFI, MassLynx, Progenesis QI |
| Compliance | 21 CFR Part 11 compatible |