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Key Features:
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Waters’ flagship ultra-sensitive triple quadrupole LC-MS/MS system for the most demanding quantitative assays.
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Seamless integration with ACQUITY UPLC I-Class for ultra-high performance liquid chromatography with maximum resolution and reproducibility.
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Incorporates StepWave™ XS ion guide technology for superior ion transfer and enhanced sensitivity over the Xevo TQ-S.
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Offers exceptionally low limits of detection (femtogram-level sensitivity) for bioanalytical and regulated workflows.
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Optimized for large-scale MRM assays, enabling high-throughput biomarker and drug quantification studies.
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Designed with robust hardware to support long-term 24/7 operation in high-demand laboratories.
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Full compatibility with MassLynx software, TargetLynx, and UNIFI for compliance-ready data acquisition and processing.
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Applications:
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Pharmaceutical Development & Clinical Research: Bioequivalence, pharmacokinetics (PK), drug metabolism (DMPK), and clinical trial support.
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Biomarker Quantification: Targeted analysis of peptides, metabolites, and small molecules at trace concentrations.
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Food Safety & Environmental Testing: Quantification of residues, contaminants, pesticides, and pollutants at ultra-trace levels.
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Forensic & Toxicology: High-sensitivity detection of drugs of abuse, toxins, and low-abundance forensic analytes.
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Regulated Laboratories: Ideal for GLP/GMP environments requiring reproducibility and 21 CFR Part 11 compliance.
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Specifications:
| Specification | Detail |
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| LC/MS Platform | Xevo TQ-XS LC-MS/MS with ACQUITY UPLC I-Class |
| MS System Type | Triple Quadrupole (TQ) Mass Spectrometer |
| Mass Range | m/z 2–2,000 |
| Resolution | Unit resolution |
| Ionization Modes | ESI, APCI |
| Autosampler | ACQUITY UPLC I-Class autosampler |
| Acquisition Modes | MRM, full scan, product ion scan, neutral loss, precursor ion scan |
| Dynamic Range | >6 orders of magnitude |
| Mass Accuracy | Nominal, optimized for quantitative reproducibility |
| Vacuum System | High-capacity turbomolecular pump system |
| Interface | StepWave XS ion guide with Z-Spray ion source |
| Software | MassLynx, TargetLynx, UNIFI |
| Compliance | 21 CFR Part 11 compatible |