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Waters Xevo TQ-XS Triple Quadrupole LC-MS/MS with ACQUITY UPLC I-Class ultra-sensitive, high-performance quantitative LC/MS system for pharmaceutical, clinical, food safety, environmental, and forensic laboratories
  • Key Features:

    • Waters’ flagship ultra-sensitive triple quadrupole LC-MS/MS system for the most demanding quantitative assays.

    • Seamless integration with ACQUITY UPLC I-Class for ultra-high performance liquid chromatography with maximum resolution and reproducibility.

    • Incorporates StepWave™ XS ion guide technology for superior ion transfer and enhanced sensitivity over the Xevo TQ-S.

    • Offers exceptionally low limits of detection (femtogram-level sensitivity) for bioanalytical and regulated workflows.

    • Optimized for large-scale MRM assays, enabling high-throughput biomarker and drug quantification studies.

    • Designed with robust hardware to support long-term 24/7 operation in high-demand laboratories.

    • Full compatibility with MassLynx software, TargetLynx, and UNIFI for compliance-ready data acquisition and processing.

  • Applications:

    • Pharmaceutical Development & Clinical Research: Bioequivalence, pharmacokinetics (PK), drug metabolism (DMPK), and clinical trial support.

    • Biomarker Quantification: Targeted analysis of peptides, metabolites, and small molecules at trace concentrations.

    • Food Safety & Environmental Testing: Quantification of residues, contaminants, pesticides, and pollutants at ultra-trace levels.

    • Forensic & Toxicology: High-sensitivity detection of drugs of abuse, toxins, and low-abundance forensic analytes.

    • Regulated Laboratories: Ideal for GLP/GMP environments requiring reproducibility and 21 CFR Part 11 compliance.

  • Specifications:

Specification Detail
LC/MS Platform Xevo TQ-XS LC-MS/MS with ACQUITY UPLC I-Class
MS System Type Triple Quadrupole (TQ) Mass Spectrometer
Mass Range m/z 2–2,000
Resolution Unit resolution
Ionization Modes ESI, APCI
Autosampler ACQUITY UPLC I-Class autosampler
Acquisition Modes MRM, full scan, product ion scan, neutral loss, precursor ion scan
Dynamic Range >6 orders of magnitude
Mass Accuracy Nominal, optimized for quantitative reproducibility
Vacuum System High-capacity turbomolecular pump system
Interface StepWave XS ion guide with Z-Spray ion source
Software MassLynx, TargetLynx, UNIFI
Compliance 21 CFR Part 11 compatible

 

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